²¹³Bi-DOTATOC is one Alpha-labeled analogue of ⁹⁰Y- and ¹⁷⁷Lu-DOTATOC. This somatostatin analogue has previously been labeled with low linear energy transfer (LET) β-emitters, such as ¹⁷⁷Lu or ⁹⁰Y, for tumor therapy. The first synthesis was initiated at the University of New Mexico, Albuquerque NM, USA but as the product is now a generic, several academic centers are exploring this molecule.
The first-in-human experience with ²¹³Bi-DOTATOC targeted Alpha therapy (TAT) in patients pretreated with beta emitters was reported in 2014.

Target/Mechanism: Somatostatin receptors

Carrier/Ligand: Edotreotide

Radiation Type: Alpha particle (α)