Th-227-Anetumab corixetan

²²⁷Th-Anetumab corixetan (²²⁷Th-BAY2287411) is a mesothelin targeted thorium conjugate (MSLN-TTC) consisting of a monoclonal antibody (anetumab) covalently linked via an amide bond to a chelator moiety (3,2-HOPO) possessing high Affinity for the Alpha-emitting Nuclide Thorium-227.

Anetumab is a human immunoglobulin G1 (IgG1) monoclonal antibody. ²²⁷Th-BAY2287411 should become a therapeutic agent directed at solid tumors expressing mesothelin. First priority is given to ovarian cancer. For Imaging purpose the analogue ⁸⁹Zr labeled Tracer was also synthesized.

A clinical study of ²²⁷Th-BAY2287411 was initiated in patients with tumors known to express mesothelin. This study involving 228 participants is expected to be completed by end of 2023.

Target/Mechanism: Mesothelin

Leading Emitter: Alpha particle (α)