Lu-177-Edotreotide (Solucin®)

¹⁷⁷Lu-Edotreotide (¹⁷⁷Lu–Octreotide, ¹⁷⁷Lu-Solucin®) is a radiolabeled somatostatin analogue developed for the treatment of NET. It is derived from the equivalent ⁹⁰Y-Edotreotide originally developed under the name Onalta®.

¹⁷⁷Lu-Edotreotide obtained the Orphan Drug designation from the EMA in July 2014 and from the FDA in June 2015 for the indication P-NET (pancreatic neuroendocrine tumors).

¹⁷⁷Lu-Edotreotide will be developed for the treatment of patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). This molecule must be considered as the first competitor for the analogue ¹⁷⁷Lu-Octreotate (¹⁷⁷Lu-Lutathera®).

A Phase III trial involving 300 patients was initiated in February 2017. This study is supposed to be completed by 2021. Another Phase III trial (COMPOSE) was initiated in September 2021.

Target/Mechanism: somatostatin receptors

Leading Emitter: beta electrons (β^–)